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Myeloperoxidase 抗体 (AA 150-250)

Name: Myeloperoxidase 抗体 (AA 150-250)
Brand: antibodies-online
SKU: ABIN7126715
Availability: OutOfStock

MPO 适用: 人 WB, IHC (f), BP 宿主: 兔 Polyclonal unconjugated

产品编号 ABIN7126715

发货至: 中国

Datasheet as PDF

抗原 See all Myeloperoxidase (MPO) 抗体

Myeloperoxidase (MPO)
抗原表位
16

15

14

14

11

9

8

6

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 150-250
适用
171

63

55

5

2

1

1

1

1

1
人
宿主
128

78

1

1

1
兔
Compatible Secondaries
克隆类型
119

90
多克隆
标记
88

32

30

12

11

10

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
This Myeloperoxidase antibody is un-conjugated
应用范围
120

87

63

61

31

28

27

18

14

14

14

13

10

8

5

5

4

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Blocking Peptide (BP)

特异性

The heme protein myeloperoxidase (MPO) is a major component of azurophilicgranules of neutrophils and polymorphonuclear leukocytes. Optimal oxygen-dependent microbiocidal activity depends on MPO as the critical enzyme forthe generation of hypochlorous acid and other toxic oxygen products. TheMPO precursor is synthesized during the promyelocytic stage of myeloid dif-ferentiation and is subsequently processed and transported intracellularly tothe lysosomes. The precursor undergoes cotranslational N-linked glycosyla-tion to produce a glycoprotein. Glucosidases in the endoplasmic reticulum(ER) or early cisGolgi convert the pro-MPO to a form which is sorted into aprelysosomal compartment, which undergoes final proteolytic maturation tonative MPO, a pair of heavy-light protomers. In normal neutrophils, MPO isexpressed as a dimer. Calreticulin, a calcium-binding protein residing in theER, interacts specifically with fully glycosylated apopro-MPO. iMPO mRNA isabundant in human promyelocytic HL-60 and mouse myeloid leukemia NFS-60cells. MPO is expressed at high levels in circulating neutrophils and mono-cytes but is not detectable in microglia, brain-specific macrophages or normalbrain tissue.MPO, which has a molecular weight of approximately 140 kD, is homodimer that can be split into two halves that still have enzymatic activity. These hemi-MPOmonomersconsist of a 59-kD alpha chainand a 13.5-kD beta chain.

交叉反应（详细）

Human.

纯化方法

1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

免疫原

Synthetic peptide corresponding to residues within aa150-250 of Myeloperoxidase was used as an immunogen.

亚型

IgG

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应用备注

Known_Application: Western Blot (2-4 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human B cell lymphoma or spleen or liver tissue.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

Prepared in 10 mM PBS, WITHOUT BSA and Azide.

储存液

Azide free

储存条件

-20 °C,-80 °C

储存方法

Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

有效期

24 months
抗原

Myeloperoxidase (MPO)

别名

MPO (MPO 产品)

别名

mKIAA4033 antibody, MPO antibody, LOC100335032 antibody, POX2' antibody, XPOX2' antibody, mpo antibody, mpo-A antibody, pmr-1 antibody, pmr1 antibody, pox2 antibody, xpox2 antibody, myeloperoxidase antibody, myeloperoxidase L homeolog antibody, MPO antibody, Mpo antibody, LOC100335032 antibody, mpo.L antibody

背景

84 kDa / 89 kDa myeloperoxidase, EC 1.11.1.7, EC1.11.2.2, fj80f04, MPO, mpx, myeloid-specific peroxidase, Myeloperoxidase, Myeloperoxidase heavy chain, Myeloperoxidase light chain,Myeloperoxidase / MPO
Cellular localisation: Cytoplasmic.

分子量

heavy-light promoter: 72kDa, dimer: 140kDa

基因ID

4353, 458272

UniProt

P05164

途径

Chromatin Binding