Cytokeratin 13 抗体
Quick Overview for Cytokeratin 13 抗体 (ABIN7126625)
抗原
See all Cytokeratin 13 (KRT13) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs)that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with Cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.
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交叉反应 （详细）
- Human, mouse, rat and rabbit.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- esophageal keratins of rabbit origin
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亚型
- IgG1
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anti-Keratin 13 (KRT13) (N-Term) antibody
KRT13 适用: 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Keratin 13 (KRT13) (AA 104-403) antibodyKRT13 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Keratin 13 (KRT13) antibodyKRT13 适用: 人 WB, IHC (p), IF, ICC, IHC (wm) 宿主: 兔 Polyclonal unconjugated
anti-Keratin 13 (KRT13) (C-Term) antibodyKRT13 适用: 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Keratin 13 (KRT13) (AA 104-458) antibodyKRT13 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7D7B3 unconjugated
anti-Keratin 13 (KRT13) (AA 269-458) antibodyKRT13 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Keratin 13 (KRT13) (AA 143-295) antibodyKRT13 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3G4 unconjugated
anti-Keratin 13 (KRT13) antibodyKRT13 适用: 人, 大鼠, 小鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 5A3 unconjugated
anti-Keratin 13 (KRT13) antibodyKRT13 适用: 人 IHC, IF, StM 宿主: 小鼠 Monoclonal KRT13-2213 unconjugated
anti-Keratin 13 (KRT13) (AA 258-357) antibodyKRT13 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F5 unconjugated
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应用备注
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Known_Application: Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or A431 cells. Skin or Squamous cell carcinoma
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))
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别名
- KRT13
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背景
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CK13, Cytokeratin-13, Keratin Type I Cytoskeletal 13, Keratin-13, KRT13, Type I Cytoskeletal 13, WSN2,Cytokeratin 13 (Non-Keratinized Squamous Epithelial Marker)
Cellular localisation: Cytoplasmic -
分子量
- 52kDa
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基因ID
- 3860, 654550
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UniProt
- P13646
抗原
-
