Recombinant IGHA1 & IGHA2 抗体
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- 抗原
- IGHA1 & IGHA2
- 抗体类型
- Recombinant Antibody
- 适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain. It reacts with the third constant domain (CH3) of the alpha chain of IgA molecules. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human IGHA1 and IGHA2 proteins
- 亚型
- IgG
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anti-IGHA1 & IGHA2 antibody
适用: 人 IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal HISA43 unconjugated
anti-IGHA1 & IGHA2 antibody适用: 人 IHC, StM 宿主: 小鼠 Monoclonal rHISA43 unconjugated Recombinant Antibody
anti-IGHA1 & IGHA2 (Internal Region) antibody适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-IGHA1 & IGHA2 antibody (CF®488A)适用: 人 IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal IA761 CF®488A
anti-IGHA1 & IGHA2 antibody适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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- 应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Daudi, 293T, Raji or hPBL cells. Human tonsil or spleen.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- IGHA1 & IGHA2
- 背景
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A2m Marker, Ig alpha 1 Chain C Region, Ig alpha 2 Chain C Region, IGHA1, IGHA2, Immunoglobulin Am1, Immunoglobulin Am2, Immunoglobulin Heavy Constant Alpha 1, Immunoglobulin Heavy Constant Alpha 2,IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker)
Cellular localisation: Cytoplasm, cell surface and secreted. - 分子量
- 50-75kDa
- 基因ID
- 699841
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