Recombinant AMH 抗体 (AA 460-560)
Quick Overview for Recombinant AMH 抗体 (AA 460-560) (ABIN7126472)
抗原
See all AMH 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 460-560
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特异性
- The transforming growth factor i² (TGFi²) superfamily is composed of numerous growth and differentiation factors, including TGFi²1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin i±,i²-A, i²-B and i²-C, Lefty and Nodal. Members of the TGFi² superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- A synthetic peptide from the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)
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亚型
- IgG
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anti-Anti-Mullerian Hormone (AMH) (AA 447-553) antibody
AMH 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 26-560) antibodyAMH 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) antibodyAMH 适用: 斑马鱼 WB, IHC 宿主: 小鼠 Monoclonal C6 unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 424-451) antibodyAMH 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 453-560) antibodyAMH 适用: 人 WB 宿主: 小鼠 Monoclonal 4-1# unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 430-460), (Middle Region) antibodyAMH 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 20-280) antibodyAMH 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 424-451) antibodyAMH 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 409-644) antibodyAMH 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 450-552) antibodyAMH 适用: 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human ovary or testis.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- AMH (Anti-Mullerian Hormone (AMH))
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别名
- AMH
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背景
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Muellerian inhibiting factor (MIF),Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS)
Cellular localisation: Secreted -
分子量
- 70kDa (reduced), 140kDa (nonreduced)
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基因ID
- 268, 112432
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途径
- Negative Regulation of Hormone Secretion
抗原
-
