AMH 抗体 (C-Term)
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Quick Overview for AMH 抗体 (C-Term) (ABIN7126471)
抗原
See all AMH 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 460-560, C-Term
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原理
- Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS) Antibody
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特异性
- The transforming growth factor æ(TGF æ) superfamily is composed of numerous growth and differentiation factors, including TGF æ1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin °™, æ-A, æ-B and æ-C, Lefty and Nodal. Members of the TGF æsuperfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
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交叉反应 （详细）
- Human, mouse, sheep and baboon.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Anti-Mullerian Hormone (AMH) (AA 447-553) antibody
AMH 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) antibodyAMH 适用: 斑马鱼 WB, IHC 宿主: 小鼠 Monoclonal C6 unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 26-560) antibodyAMH 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 424-451) antibodyAMH 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 453-560) antibodyAMH 适用: 人 WB 宿主: 小鼠 Monoclonal 4-1# unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 424-451) antibodyAMH 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 430-460), (Middle Region) antibodyAMH 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 409-644) antibodyAMH 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 19-560) antibodyAMH 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal J17 unconjugated
anti-Anti-Mullerian Hormone (AMH) (AA 468-517) antibodyAMH 适用: 人, 小鼠, 大鼠, Pig, Cow, 犬, 豚鼠, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human or mouse ovary tissue.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- AMH (Anti-Mullerian Hormone (AMH))
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别名
- AMH
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背景
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Muellerian inhibiting factor (MIF)
Human or mouse ovary tissue.
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分子量
- 70kDa (reduced), 140kDa (nonreduced)
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基因ID
- 268, 112432
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途径
- Negative Regulation of Hormone Secretion
抗原
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