GRAMD4 抗体
This anti-GRAMD4 antibody is a 小鼠 单克隆 antibody detecting GRAMD4 in FACS 和 IF. Suitable for 人.
Quick Overview for GRAMD4 抗体 (ABIN7126410)
抗原
See all GRAMD4 抗体
GRAMD4
(GRAM Domain Containing 4 (GRAMD4))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This GRAMD4 antibody is un-conjugated
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF)
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特异性
- The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
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交叉反应 （详细）
- Human. Predicted to react in Rat.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human GRAMD4 protein
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亚型
- IgG1
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anti-GRAM Domain Containing 4 (GRAMD4) (AA 23-161) antibody
GRAMD4 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: Human liver, heart or fetal brain.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- GRAMD4 (GRAM Domain Containing 4 (GRAMD4))
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别名
- GRAMD4
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背景
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Death-inducing protein, GRAM domain-containing protein 4 (GRAMD4),GRAMD4 (Transcription Factor)
Cellular localisation: Mitochondrion membrane. Colocalizes with COX4I1. -
分子量
- 66kDa
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基因ID
- 23151, 475150
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UniProt
- Q6IC98
抗原
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