ETS2 抗体
Quick Overview for ETS2 抗体 (ABIN7126356)
抗原
See all ETS2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- ETS2 (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. ETS2 was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. ETS2 protein expression is complex and changes throughout development. ETS2 appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.
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交叉反应 (详细)
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human ETS2 protein
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亚型
- IgG2b
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), ,Flow Cytometry (1-2 μg/million cells),Immunofluorescence (1-2 μg/mL), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Optimal dilution for a specific application should be determined.
Positive_Control: Human thymus, lung or cerebellum.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))
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别名
- ETS2
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背景
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C ets 2 protein, ETS2, ETS2IT1, Oncogene ETS2, Protein C-ets-2, v ets avian erythroblastosis virus E2 oncogene homolog 2, V ets avian erythroblastosis virus E26 oncogene homolog 2,ETS2 (Transcription Factor)
Cellular localisation: Nucleus. -
分子量
- 52kDa
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基因ID
- 2114, 644231
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UniProt
- P15036
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途径
- EGFR Signaling Pathway, Myometrial Relaxation and Contraction
抗原
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