EIF2C3 抗体
Quick Overview for EIF2C3 抗体 (ABIN7126312)
抗原
See all EIF2C3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antigen is involved in binding and translation repression of short RNAs. This antigen is also known as argonaute RISC catalytic component 3.Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human AGO3 protein
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亚型
- IgG1
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anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) (AA 1-100) antibody
EIF2C3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) (Internal Region) antibodyEIF2C3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) antibodyEIF2C3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) (AA 251-400) antibodyEIF2C3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) (AA 1-626) antibodyEIF2C3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) (AA 160-209) antibodyEIF2C3 适用: 人, 小鼠, Cow, 大鼠, 斑马鱼, 犬, 马, Pig, 兔, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) (N-Term) antibodyEIF2C3 适用: 人, 小鼠, Cow, 大鼠, 斑马鱼, 犬, 马, Pig, 兔, 小鸡, 非洲爪蟾, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) (N-Term) antibodyEIF2C3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2C3 (EIF2C3) antibodyKD Validated EIF2C3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MCF7 or U-2OS cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- EIF2C3 (Eukaryotic Translation Initiation Factor 2C3 (EIF2C3))
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别名
- AGO3
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背景
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Argonaute 3, Argonaute3, eIF 2C 3, eIF-2C 3, eIF2C 3, Eif2c3, EIF2C3 protein, Eukaryotic translation initiation factor 2C 3, Eukaryotic translation initiation factor 2C3, FLJ12765, hAgo3, MGC86946, Protein argonaute-3,AGO3 (Argonaute-3) / eIF2C3
Cellular localisation: Cytoplasm>P-bodies. Nucleoplasm. -
分子量
- 97.36kDa
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基因ID
- 192669, 657659
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UniProt
- Q9H9G7
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途径
- Fc-epsilon Receptor Signaling Pathway, Regulatory RNA Pathways, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
-
