CDX1 抗体
Quick Overview for CDX1 抗体 (ABIN7504134)
抗原
See all CDX1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila caudal gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q32 and encodes a 265-amino acid protein.
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交叉反应 （详细）
- Human.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant human full-length CDX1 protein
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亚型
- IgG1
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anti-Caudal Type Homeobox 1 (CDX1) (AA 126-215) antibody
CDX1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D8 unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 126-215) antibodyCDX1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 122-227) antibodyCDX1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1B11A9 unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 206-245) antibodyCDX1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 236-265), (C-Term) antibodyCDX1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1820 unconjugated
anti-Caudal Type Homeobox 1 (CDX1) antibodyCDX1 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 7C2 unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 238-287) antibodyCDX1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 马, 斑马鱼, Pig, 豚鼠, Bat, 小鸡, 猴, 非洲爪蟾, Drosophila melanogaster WB 宿主: 兔 Polyclonal unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 1-139) antibodyCDX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 195-244) antibodyCDX1 适用: 人, 小鼠, 大鼠, 犬, 马, 豚鼠, Bat, 小鸡, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Caudal Type Homeobox 1 (CDX1) (AA 31-80) antibodyCDX1 适用: 人, 小鼠, Cow, 兔, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: HT29 cells. Colon Carcinoma
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
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有效期
- 24 months
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- CDX1 (Caudal Type Homeobox 1 (CDX1))
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别名
- CDX1
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背景
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Caudal type homeobox 1, Caudal type homeobox transcription factor 1, Caudal-type homeobox protein 1,CDX1,CDX1 / Caudal Type Homeobox 1 (Intestine-Specific Transcription Factor)
Cellular localisation: Nuclear -
分子量
- 28kDa
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基因ID
- 1044, 1545
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UniProt
- P47902
抗原
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