ZCCHC6 抗体
Quick Overview for ZCCHC6 抗体 (ABIN7121053)
抗原
See all ZCCHC6 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TUT7 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- zinc finger, CCHC domain containing 6
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亚型
- IgG
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anti-Zinc Finger, CCHC Domain Containing 6 (ZCCHC6) (AA 1-412) antibody
ZCCHC6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:5000, IP: 1:500-1:5000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ZCCHC6 (Zinc Finger, CCHC Domain Containing 6 (ZCCHC6))
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别名
- TUT7
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背景
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Synonyms: Terminal uridylyltransferase 7 (TUTase 7)|Zinc finger CCHC domain-containing protein 6|TUT7|HS2|KIAA1711|ZCCHC6
Background: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:19703396, PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets(PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A(PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
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分子量
- 171 kDa
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基因ID
- 79670
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UniProt
- Q5VYS8
抗原
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