YTHDF2 抗体
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北京 101111
Quick Overview for YTHDF2 抗体 (ABIN7120904)
抗原
See all YTHDF2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- YTHDF2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- YTH domain family, member 2
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亚型
- IgG
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anti-YTH Domain Family, Member 2 (YTHDF2) (AA 201-500) antibody
YTHDF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Family, Member 2 (YTHDF2) antibodyYTHDF2 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Family, Member 2 (YTHDF2) (AA 1-579) antibodyYTHDF2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:1000-1:10000, IF: 1:10-1:100, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))
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别名
- YTHDF2
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背景
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Synonyms: YTH domain-containing family protein 2 (DF2)|CLL-associated antigen KW-14|High-glucose-regulated protein 8|Renal carcinoma antigen NY-REN-2|YTHDF2|HGRG8
Background: Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, and regulates mRNA stability(PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies(P-bodies), leading to mRNA degradation(PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation(PubMed:26458103).
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分子量
- 68 kDa
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基因ID
- 51441
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UniProt
- Q9Y5A9
抗原
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