YTHDC1 抗体
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北京 101111
Quick Overview for YTHDC1 抗体 (ABIN7120901)
抗原
See all YTHDC1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- YTHDC1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- YTH domain containing 1
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亚型
- IgG
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anti-YTH Domain Containing 1 (YTHDC1) (AA 260-500) antibody
YTHDC1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Containing 1 (YTHDC1) (AA 89-153) antibodyYTHDC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Containing 1 (YTHDC1) antibodyYTHDC1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Containing 1 (YTHDC1) antibodyYTHDC1 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- YTHDC1 (YTH Domain Containing 1 (YTHDC1))
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别名
- YTHDC1
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背景
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Synonyms: YTH domain-containing protein 1|Splicing factor YT521 (YT521-B)|YTHDC1|KIAA1966|YT521
Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).
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分子量
- 110 kDa
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基因ID
- 91746
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UniProt
- Q96MU7
抗原
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