VPS4A 抗体
Quick Overview for VPS4A 抗体 (ABIN7120723)
抗原
See all VPS4A 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- VPS4A antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- vacuolar protein sorting 4 homolog A
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亚型
- IgG
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anti-Vacuolar Protein Sorting-Associated Protein 4A (VPS4A) (AA 1-120) antibody
VPS4A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting-Associated Protein 4A (VPS4A) (N-Term) antibodyVPS4A 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting-Associated Protein 4A (VPS4A) antibodyVPS4A 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting-Associated Protein 4A (VPS4A) (AA 44-77), (N-Term) antibodyVPS4A 适用: 人 WB 宿主: 兔 Polyclonal RB49739 unconjugated
anti-Vacuolar Protein Sorting-Associated Protein 4A (VPS4A) (AA 1-437) antibodyVPS4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Vacuolar Protein Sorting-Associated Protein 4A (VPS4A) (AA 74-123) antibodyVPS4A 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting-Associated Protein 4A (VPS4A) (AA 38-87) antibodyVPS4A 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 斑马鱼, Hamster, 猴, Bat, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))
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别名
- VPS4A
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背景
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Synonyms: Vacuolar protein sorting-associated protein 4A|Protein SKD2|VPS4-1 (hVPS4)|VPS4A|VPS4
Background: Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission(PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).
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分子量
- 49 kDa
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基因ID
- 27183
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UniProt
- Q9UN37
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途径
- Microtubule Dynamics, CXCR4-mediated Signaling Events
抗原
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