VPS35 抗体
Quick Overview for VPS35 抗体 (ABIN7120708)
抗原
See all VPS35 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- VPS35 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- vacuolar protein sorting 35 homolog
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亚型
- IgG
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anti-Vacuolar Protein Sorting 35 (VPS35) (C-Term) antibody
VPS35 适用: 人, 小鼠, 大鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting 35 (VPS35) (C-Term) antibodyVerified VPS35 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Vacuolar Protein Sorting 35 (VPS35) antibodyVPS35 适用: 人 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal 8A3 unconjugated
anti-Vacuolar Protein Sorting 35 (VPS35) antibodyVPS35 适用: 人 WB, IHC, IP 宿主: 小鼠 Monoclonal 11H10 unconjugated
anti-Vacuolar Protein Sorting 35 (VPS35) antibodyVPS35 适用: 人 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal 7E4 unconjugated
anti-Vacuolar Protein Sorting 35 (VPS35) antibodyVPS35 适用: 人 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal 5A9 unconjugated
anti-Vacuolar Protein Sorting 35 (VPS35) antibodyVPS35 适用: 人 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal 10A8 unconjugated
anti-Vacuolar Protein Sorting 35 (VPS35) antibody (HRP)VPS35 适用: 人 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal 5A9 HRP
anti-Vacuolar Protein Sorting 35 (VPS35) antibody (HRP)VPS35 适用: 人 WB, IHC, IP 宿主: 小鼠 Monoclonal 11H10 HRP
anti-Vacuolar Protein Sorting 35 (VPS35) antibody (HRP)VPS35 适用: 人 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal 10A8 HRP
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应用备注
- WB: 1:200-1:1000, IP: 1:200-1:1000, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- VPS35 (Vacuolar Protein Sorting 35 (VPS35))
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别名
- VPS35
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背景
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Synonyms: Vacuolar protein sorting-associated protein 35 (hVPS35)|Maternal-embryonic 3|Vesicle protein sorting 35|VPS35|MEM3
Background: Acts as component of the retromer cargo-selective complex(CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35, however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5(Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor(pIgR-pIgA)(PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of FAM21C(PubMed:22070227). Mediates the association of the CSC with the WASH complex via FAM21(PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5(PubMed:20923837).
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分子量
- 92 kDa
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基因ID
- 55737
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UniProt
- Q96QK1
抗原
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