Uromodulin 抗体 (AA 300-587)
Quick Overview for Uromodulin 抗体 (AA 300-587) (ABIN7120648)
抗原
See all Uromodulin (UMOD) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 300-587
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原理
- UMOD antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 300-587aa
Immunogen: uromodulin
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亚型
- IgG
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应用备注
- WB: 1:200-1:2000, IHC: 1:20-1:500, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- Uromodulin (UMOD)
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别名
- UMOD
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背景
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Synonyms: Uromodulin|Tamm-Horsfall urinary glycoprotein (THP)|Uromodulin, secreted form|UMOD
Background: Uromodulin, also known as THP(Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases.(PMID: 21654721)
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分子量
- 55-70 kDa
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UniProt
- P07911
抗原
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