GALE 抗体
Quick Overview for GALE 抗体 (ABIN7120594)
抗原
See all GALE 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- GALE antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- UDP-galactose-4-epimerase
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亚型
- IgG
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应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- GALE (UDP-Galactose-4-Epimerase (GALE))
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别名
- GALE
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背景
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Synonyms: UDP-glucose 4-epimerase|Galactowaldenase|UDP-N-acetylgalactosamine 4-epimerase (UDP-GalNAc 4-epimerase)|UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase)|UDP-galactose 4-epimerase|GALE
Background: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
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分子量
- 36 kDa
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基因ID
- 2582
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UniProt
- Q14376
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途径
- Response to Water Deprivation, Cellular Glucan Metabolic Process
抗原
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