Synonyms:E1 L2, FLJ10808, FLJ23367, Monocyte protein 4, MOP 4, MOP4, UBA6, UBE1L2, Ubiquitin activating enzyme 6 Background:Modification of proteins with ubiquitin (UBB, MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).