USP2 抗体
Quick Overview for USP2 抗体 (ABIN7120503)
抗原
See all USP2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- USP2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ubiquitin specific peptidase 2
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 508-538), (C-Term) antibody
USP2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4417 unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 71-101), (N-Term) antibodyUSP2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4202 unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 200-430) antibodyUSP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) antibodyUSP2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibodyUSP2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 9-265) antibodyUSP2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-258) antibodyUSP2 适用: 人, Green Monkey WB 宿主: 小鼠 Monoclonal 1738CT331-50-87 unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 371-420) antibodyUSP2 适用: 人, 犬, 马, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibodyUSP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:2000, IHC: 1:20-1:200,IF:1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- USP2 (Ubiquitin Specific Peptidase 2 (USP2))
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别名
- USP2
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背景
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Synonyms: Ubiquitin carboxyl-terminal hydrolase 2|41 kDa ubiquitin-specific protease|Deubiquitinating enzyme 2|Ubiquitin thioesterase 2|Ubiquitin-specific-processing protease 2|USP2|UBP41
Background: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1(By similarity).
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分子量
- 68 kDa
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基因ID
- 10869
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UniProt
- O75604
抗原
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