USP11 抗体
Quick Overview for USP11 抗体 (ABIN7120493)
抗原
See all USP11 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- USP11 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ubiquitin specific peptidase 11
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亚型
- IgG
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应用备注
- WB: 1:500-1:5000, IHC: 1:20-1:200, IP: 1:1000-1:10000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- USP11 (Ubiquitin Specific Peptidase 11 (USP11))
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别名
- USP11
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背景
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Synonyms: Ubiquitin carboxyl-terminal hydrolase 11|Deubiquitinating enzyme 11|Ubiquitin thioesterase 11|Ubiquitin-specific-processing protease 11|USP11|UHX1
Background: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains(PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome(PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains(in vitro)(PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation(PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks(PubMed:15314155, PubMed:20233726).
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分子量
- 110 kDa
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基因ID
- 8237
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UniProt
- P51784
抗原
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