USP10 抗体
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- 抗原 See all USP10 抗体
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This USP10 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- ubiquitin specific peptidase 10
- 亚型
- IgG
- Top Product
- Discover our top product USP10 Primary Antibody
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anti-Ubiquitin Specific Peptidase 10 (USP10) antibody
USP10 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1A10 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人, 猴 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1H9 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 1-798) antibodyUSP10 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 699-797) antibodyUSP10 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 1-798) antibodyUSP10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 499-798) antibodyUSP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (N-Term) antibodyUSP10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (C-Term) antibodyUSP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:5000, IP: 1:200-1:2000, IF: 1:10-1:100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
- 别名
- USP10 (USP10 产品)
- 背景
- Synonyms:Deubiquitinating enzyme 10, KIAA0190, Ubiquitin thiolesterase 10, UBPO, USP10 Background:Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989).
- 分子量
- 100 kDa
- 基因ID
- 9100
- UniProt
- Q14694
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