TFG 抗体
Quick Overview for TFG 抗体 (ABIN7120305)
抗原
See all TFG 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TFG antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- TRK-fused gene
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亚型
- IgG
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anti-Trk-Fused Gene (TFG) (AA 1-240) antibody
TFG 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Trk-Fused Gene (TFG) (AA 1-400) antibodyTFG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Trk-Fused Gene (TFG) (AA 1-110) antibodyTFG 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Trk-Fused Gene (TFG) antibodyTFG 适用: 人 WB, IP, ICC 宿主: 小鼠 Monoclonal TFG-03 unconjugated
anti-Trk-Fused Gene (TFG) (AA 1-240) antibodyTFG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:50-1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- TFG (Trk-Fused Gene (TFG))
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别名
- TFG
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背景
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Synonyms: Protein TFG|TRK-fused gene protein|TFG
Background: Protein TFG(TRK-fused gene protein) plays a role in regulating phosphotyrosine-specific phosphatase-1 activity. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. Defects in TFG are a cause of thyroid papillary carcinoma(TPC), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Hereditary motor and sensory neuropathy with proximal dominant involvement(HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, and atrophy followed by distal sensory involvement. Recent genetic investigation indicates that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TAR DNA-binding protein 43 kDa(TDP-43) underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.
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分子量
- 50-55 kDa
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UniProt
- Q92734
抗原
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