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TRAIP 抗体

This anti-TRAIP antibody (ABIN7120031) is a Rabbit Polyclonal antibody detecting TRAIP in ELISA, IHC, WB, IF. Suitable for Human, Mouse.
产品编号 ABIN7120031
发货至: 中国

Quick Overview for TRAIP 抗体 (ABIN7120031)

抗原

See all TRAIP 抗体
TRAIP (TRAF Interacting Protein (TRAIP))

适用

  • 21
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  • 2
人, 小鼠

宿主

  • 16
  • 4
  • 1

克隆类型

  • 18
  • 3
多克隆

标记

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This TRAIP antibody is un-conjugated

应用范围

  • 12
  • 9
  • 6
  • 4
  • 3
  • 2
  • 1
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  • 1
ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    TRAF interacting protein

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    TRAIP (TRAF Interacting Protein (TRAIP))

    别名

    TRAIP

    背景

    Synonyms:RNF206, TRIP Background:E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).

    分子量

    53 kDa

    基因ID

    10293

    UniProt

    Q9BWF2
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