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TJP1 抗体 (AA 480-742)

This anti-TJP1 antibody is a 兔 多克隆 antibody detecting TJP1 in WB, IHC, IP, ELISA, IF 和 FACS. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7119969
发货至: 中国

Quick Overview for TJP1 抗体 (AA 480-742) (ABIN7119969)

抗原

See all TJP1 抗体
TJP1 (Tight Junction Protein 1 (TJP1))

适用

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人, 小鼠, 大鼠

宿主

  • 57
  • 5
  • 3
  • 1
  • 1

克隆类型

  • 58
  • 9
多克隆

标记

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This TJP1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)
  • 抗原表位

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    AA 480-742

    原理

    TJP1 antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Immunogen sequence: 480-742aa

    Immunogen: tight junction protein 1(zona occludens 1)

    亚型

    IgG
  • 应用备注

    WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:50-1:200, IF: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    TJP1 (Tight Junction Protein 1 (TJP1))

    别名

    TJP1

    背景

    Synonyms: Tight junction protein ZO-1|Tight junction protein 1|Zona occludens protein 1|Zonula occludens protein 1|TJP1|ZO1

    Background: Tight junction(or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium(PMID: 20066090). ZO-1(also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells(PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin(PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs(MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regulating cell proliferation and differentiation(PMID: 22782886).

    分子量

    230 kDa

    基因ID

    7082

    UniProt

    Q07157

    途径

    Carbohydrate Homeostasis, Cell-Cell Junction Organization
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