TSPAN12 抗体
Our Local Distributor
北京 101111
Quick Overview for TSPAN12 抗体 (ABIN7119860)
抗原
See all TSPAN12 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- TSPAN12 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- tetraspanin 12
-
亚型
- IgG
-
-
anti-Tetraspanin 12 (TSPAN12) (AA 111-224) antibody
TSPAN12 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 111-224) antibodyTSPAN12 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 185-234) antibodyTSPAN12 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, Bat, 猴, Pig WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 232-259), (C-Term) antibodyTSPAN12 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22652 unconjugated
anti-Tetraspanin 12 (TSPAN12) antibodyTSPAN12 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 1-100) antibodyTSPAN12 适用: 人, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 179-228) antibodyTSPAN12 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (Middle Region) antibodyTSPAN12 适用: 人, 大鼠, 小鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:200-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- TSPAN12 (Tetraspanin 12 (TSPAN12))
-
别名
- TSPAN12
-
背景
-
Synonyms: Tetraspanin-12 (Tspan-12)|Tetraspan NET-2|Transmembrane 4 superfamily member 12|TSPAN12|NET2|TM4SF12
Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
-
分子量
- 28 kDa
-
基因ID
- 23554
-
UniProt
- O95859
抗原
-
