TEAD4 抗体
Quick Overview for TEAD4 抗体 (ABIN7119813)
抗原
See all TEAD4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TEAD4 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- TEA domain family member 4
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- TEAD4 (TEA Domain Family Member 4 (TEAD4))
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别名
- TEAD4
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背景
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Synonyms: Transcriptional enhancer factor TEF-3|TEA domain family member 4 (TEAD-4)|Transcription factor 13-like 1|Transcription factor RTEF-1|TEAD4|RTEF1|TCF13L1|TEF3
Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons'(5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
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分子量
- 50-55 kDa
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基因ID
- 7004
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UniProt
- Q15561
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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