SMC5 抗体
Quick Overview for SMC5 抗体 (ABIN7119560)
抗原
See all SMC5 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SMC5 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- structural maintenance of chromosomes 5
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亚型
- IgG
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anti-Structural Maintenance of Chromosomes 5 (SMC5) (Internal Region) antibody
Verified SMC5 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 872-1101) antibodySMC5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 296-403) antibodySMC5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 992-1101) antibodySMC5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))
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别名
- SMC5
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背景
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Synonyms: Structural maintenance of chromosomes protein 5 (SMC protein 5, SMC-5, hSMC5)|SMC5|KIAA0594|SMC5L1
Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).
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分子量
- 120-130 kDa
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基因ID
- 23137
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UniProt
- Q8IY18
抗原
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