SREBF chaperone 抗体
Quick Overview for SREBF chaperone 抗体 (ABIN7119463)
抗原
See all SREBF chaperone (SCAP) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- SREBF chaperone
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亚型
- IgG
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anti-SREBF chaperone (SCAP) (AA 604-632) antibody
SCAP 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22508 unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SREBF chaperone (SCAP) antibodySCAP 适用: 人 WB, IHC, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-SREBF chaperone (SCAP) (AA 49-83), (N-Term) antibodySCAP 适用: 人 WB 宿主: 小鼠 Monoclonal 1992C245-37-16 unconjugated
anti-SREBF chaperone (SCAP) (AA 977-1194) antibodySCAP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- SREBF chaperone (SCAP)
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别名
- SCAP
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背景
- Synonyms:KIAA0199 Background:Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway(By similarity).SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt: Q12770).
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分子量
- 140 kDa,96 kDa
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基因ID
- 22937
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UniProt
- Q12770
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途径
- SARS-CoV-2 Protein Interactome
抗原
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