SART3 抗体
Quick Overview for SART3 抗体 (ABIN7119454)
抗原
See all SART3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SART3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- squamous cell carcinoma antigen recognized by T cells 3
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:500-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SART3 (Squamous Cell Carcinoma Antigen Recognized By T Cells 3 (SART3))
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别名
- SART3
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背景
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Synonyms: Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3)|Tat-interacting protein of 110 kDa (Tip110)|p110 nuclear RNA-binding protein|SART3|KIAA0156|TIP110
Background: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation(PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites(PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly(PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair(PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC(By similarity).
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分子量
- 110 kDa
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基因ID
- 9733
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UniProt
- Q15020
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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