SIX2 抗体
Quick Overview for SIX2 抗体 (ABIN7119117)
抗原
See all SIX2 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- SIX homeobox 2
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亚型
- IgG
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anti-SIX Homeobox 2 (SIX2) (AA 1-291) antibody
SIX2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3D7 unconjugated
anti-SIX Homeobox 2 (SIX2) (Internal Region) antibodySIX2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SIX Homeobox 2 (SIX2) (C-Term) antibodySIX2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SIX Homeobox 2 (SIX2) antibodySIX2 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-SIX Homeobox 2 (SIX2) (AA 35-84) antibodySIX2 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 豚鼠, 马, 绵羊, 斑马鱼, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:1000, IP: 1:500-1:1000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- SIX2 (SIX Homeobox 2 (SIX2))
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别名
- SIX2
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背景
- Synonyms:Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2 Background:Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development(By similarity). Plays a role in cell proliferation and migration.
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分子量
- 35 kDa
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基因ID
- 10736
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UniProt
- Q9NPC8
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途径
- Protein targeting to Nucleus
抗原
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