SIRT5 抗体
Quick Overview for SIRT5 抗体 (ABIN7119113)
抗原
See all SIRT5 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- SIRT5 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- sirtuin(silent mating type information regulation 2 homolog) 5
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:1000, IP: 1:500-1:1000, IF: 1:50-1:500
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- SIRT5 (Sirtuin 5 (SIRT5))
-
别名
- SIRT5
-
背景
-
Synonyms: NAD-dependent protein deacylase sirtuin-5, mitochondrial|Regulatory protein SIR2 homolog 5|SIR2-like protein 5|SIRT5|SIR2L5
Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX.
-
分子量
- 33 kDa
-
UniProt
- Q9NXA8
-
途径
- SARS-CoV-2 Protein Interactome
抗原
-