SH2D1B 抗体
Quick Overview for SH2D1B 抗体 (ABIN7119007)
抗原
See all SH2D1B 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SH2D1B antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- SH2 domain containing 1B
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亚型
- IgG
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anti-SH2 Domain Containing 1B (SH2D1B) (AA 1-77) antibody
SH2D1B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1B (SH2D1B) (AA 1-132) antibodySH2D1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1B (SH2D1B) (AA 54-132) antibodySH2D1B 适用: 人 ELISA, IP 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-SH2 Domain Containing 1B (SH2D1B) (AA 1-132) antibodySH2D1B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SH2D1B (SH2 Domain Containing 1B (SH2D1B))
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别名
- SH2D1B
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背景
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Synonyms: SH2 domain-containing protein 1B|EWS/FLI1-activated transcript 2 (EAT-2)|SH2D1B|EAT2
Background: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule(SLAM) family such as CD84, SLAMF1, LY9 and CD244(PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer(NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation, downstream signaling involves PLCG1 and ERK activation(PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling(By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse(PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation(By similarity).
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分子量
- 15 kDa
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基因ID
- 117157
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UniProt
- O14796
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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