RBM25 抗体
Quick Overview for RBM25 抗体 (ABIN7118681)
抗原
See all RBM25 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- RBM25 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- RNA binding motif protein 25
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亚型
- IgG
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anti-RNA Binding Motif Protein 25 (RBM25) (AA 614-843) antibody
RBM25 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 25 (RBM25) (AA 285-334) antibodyRBM25 适用: 小鼠, 人, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RBM25 (RNA Binding Motif Protein 25 (RBM25))
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别名
- RBM25
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背景
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Synonyms: RNA-binding protein 25|Arg/Glu/Asp-rich protein of 120 kDa (RED120)|Protein S164|RNA-binding motif protein 25|RNA-binding region-containing protein 7|RBM25|RNPC7
Background: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site(5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
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分子量
- 110-120 kDa
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基因ID
- 58517
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UniProt
- P49756
抗原
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