RGMA 抗体
Quick Overview for RGMA 抗体 (ABIN7118468)
抗原
See all RGMA 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- RGMA antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- RGM domain family, member A
-
亚型
- IgG
-
-
anti-RGM Domain Family, Member A (RGMA) (AA 153-408) antibody
RGMA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RGM Domain Family, Member A (RGMA) (AA 326-423) antibodyRGMA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6D7 unconjugated
anti-RGM Domain Family, Member A (RGMA) antibodyRGMA 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
-
-
应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- RGMA (RGM Domain Family, Member A (RGMA))
-
别名
- RGMA
-
背景
-
Synonyms: Repulsive guidance molecule A|RGM domain family member A|RGMA|RGM
Background: Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
-
分子量
- 49 kDa
-
基因ID
- 56963
-
UniProt
- Q96B86
-
途径
- Tube Formation
抗原
-
