RORC 抗体
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- 抗原 See all RORC 抗体
- RORC (RAR-Related Orphan Receptor C (RORC))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RORC antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- RAR-related orphan receptor C
- 亚型
- IgG
- Top Product
- Discover our top product RORC Primary Antibody
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anti-RAR-Related Orphan Receptor C (RORC) (AA 212-461) antibody
RORC 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 200-212) antibodyVerified RORC 适用: 人 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (N-Term) antibodyRORC 适用: 人, 小鼠, 大鼠, Cow, 马, 犬, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (Middle Region) antibodyRORC 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 110-159) antibodyRORC 适用: 人, Cow, 马, 豚鼠, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 412-517) antibodyRORC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50) antibodyRORC 适用: 人, 小鼠 WB, FACS 宿主: 小鼠 Monoclonal 4G419 unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 1-518) antibodyRORC 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) antibodyRORC 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) antibodyRORC 适用: 人 ELISA, Coat 宿主: 小鼠 Monoclonal RORC-2942 unconjugated
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- 应用备注
- WB: 1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- RORC (RAR-Related Orphan Receptor C (RORC))
- 别名
- RORC (RORC 产品)
- 别名
- NR1F3 antibody, RORG antibody, RZR-GAMMA antibody, RZRG antibody, TOR antibody, Nr1f3 antibody, RORgamma antibody, Thor antibody, RAR related orphan receptor C antibody, RAR-related orphan receptor C antibody, RAR-related orphan receptor gamma antibody, RORC antibody, Rorc antibody
- 背景
- Synonyms:NR1F3, Nuclear receptor ROR gamma, Nuclear receptor RZR gamma, RAR related orphan receptor C, RORC, RORG, RZR GAMMA, RZRG, TOR Background:Nuclear receptor that binds DNA as a monomer to ROR response elements(RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism(PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists(25-hydroxycholesterol) or inverse agonists(7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively(PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A(PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1(PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization(PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity(PubMed:26160376). Isoform 2: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi(lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper(T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2(CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus.
- 分子量
- 58 kDa
- 基因ID
- 6097
- UniProt
- P51449
- 途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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