RAN 抗体 (AA 1-216)
Quick Overview for RAN 抗体 (AA 1-216) (ABIN7118276)
抗原
See all RAN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-216
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原理
- RAN antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 1-216aa
Immunogen: RAN, member RAS oncogene family
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RAN (RAN, Member RAS Oncogene Family (RAN))
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别名
- RAN
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背景
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Synonyms: GTP-binding nuclear protein Ran|Androgen receptor-associated protein 24|GTPase Ran|Ras-like protein TC4|Ras-related nuclear protein|RAN|ARA24
Background: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle(By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
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分子量
- 24 kDa
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基因ID
- 5901
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UniProt
- P62826
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途径
- Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
抗原
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