R-Spondin 3 抗体
Quick Overview for R-Spondin 3 抗体 (ABIN7118173)
抗原
See all R-Spondin 3 (RSPO3) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- R-spondin 3 homolog
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亚型
- IgG
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anti-R-Spondin 3 (RSPO3) (AA 22-272) antibody
RSPO3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 3 (RSPO3) (AA 22-272) antibodyRSPO3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 3 (RSPO3) (AA 197-230) antibodyRSPO3 适用: 人 WB 宿主: 兔 Polyclonal RB54572 unconjugated
anti-R-Spondin 3 (RSPO3) (AA 214-248) antibodyRSPO3 适用: 人 WB 宿主: 兔 Polyclonal RB54573 unconjugated
anti-R-Spondin 3 (RSPO3) (AA 202-251) antibodyRSPO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-R-Spondin 3 (RSPO3) (AA 1-100) antibodyRSPO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:1000, IHC: 1:100-1:400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- R-Spondin 3 (RSPO3)
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别名
- RSPO3
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背景
- Synonyms:CRISTIN1, hPWTSR, hRspo3, Protein with TSP type 1 repeat, PWTSR, R spondin 3, Roof plate specific spondin 3, RSPO3, THSD2 Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway(PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells(By similarity).
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分子量
- 40 kDa
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基因ID
- 84870
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UniProt
- Q9BXY4
抗原
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