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PKN2 抗体

This anti-PKN2 antibody is a Rabbit Polyclonal antibody detecting PKN2 in WB, ELISA, IP, IF, FACS. Suitable for Human, Mouse, Rat.
产品编号 ABIN7117963
发货至: 中国

Quick Overview for PKN2 抗体 (ABIN7117963)

抗原

See all PKN2 抗体
PKN2 (Protein Kinase N2 (PKN2))

适用

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人, 小鼠, 大鼠

宿主

  • 51
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克隆类型

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多克隆

标记

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This PKN2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    protein kinase N2

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    PKN2 (Protein Kinase N2 (PKN2))

    别名

    PKN2

    背景

    Synonyms:PRK2, PRKCL2 Background:PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor(SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.

    分子量

    130 kDa

    基因ID

    5586

    UniProt

    Q16513

    途径

    Cell-Cell Junction Organization
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