PACSIN1 抗体
Quick Overview for PACSIN1 抗体 (ABIN7117945)
抗原
See all PACSIN1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PACSIN1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- protein kinase C and casein kinase substrate in neurons 1
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PACSIN1 (Protein Kinase C and Casein Kinase Substrate in Neurons 1 (PACSIN1))
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别名
- PACSIN1
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背景
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Synonyms: Protein kinase C and casein kinase substrate in neurons protein 1|Syndapin-1|PACSIN1|KIAA1379
Background: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT, this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis, this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission(By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
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分子量
- 48-51 kDa
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基因ID
- 29993
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UniProt
- Q9BY11
抗原
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