PRMT1 抗体
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北京 101111
Quick Overview for PRMT1 抗体 (ABIN7117926)
抗原
See all PRMT1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PRMT1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- protein arginine methyltransferase 1
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亚型
- IgG
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anti-Protein Arginine Methyltransferase 1 (PRMT1) (AA 20-353) antibody
PRMT1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) antibodyPRMT1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) (AA 1-248) antibodyPRMT1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) (C-Term) antibodyPRMT1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) antibodyPRMT1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) (AA 20-353) antibodyPRMT1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) (AA 171-220) antibodyPRMT1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 斑马鱼, 豚鼠, 非洲爪蟾, Hamster, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) (Middle Region) antibodyPRMT1 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) (AA 317-346), (C-Term) antibodyPRMT1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB15344 unconjugated
anti-Protein Arginine Methyltransferase 1 (PRMT1) (AA 317-346) antibodyPRMT1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))
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别名
- PRMT1
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背景
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Synonyms: Protein arginine N-methyltransferase 1|Histone-arginine N-methyltransferase PRMT1|Interferon receptor 1-bound protein 4|PRMT1|HMT2|HRMT1L2|IR1B4
Background: Arginine methyltransferase that methylates(mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4'(H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma(IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor(ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine(5hmC)-binding activity(PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP-and/or TET1-dependent manner(PubMed:25284789).
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分子量
- 40-42 kDa
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基因ID
- 3276
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UniProt
- Q99873
抗原
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