PSTPIP1 抗体
Quick Overview for PSTPIP1 抗体 (ABIN7117827)
抗原
See all PSTPIP1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PSTPIP1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- proline-serine-threonine phosphatase interacting protein 1
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亚型
- IgG
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anti-Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) (AA 1-416) antibody
PSTPIP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D5 unconjugated
anti-Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) (AA 157-416) antibodyPSTPIP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) (AA 157-416) antibodyPSTPIP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) (AA 89-118), (N-Term) antibodyPSTPIP1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB31127 unconjugated
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应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))
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别名
- PSTPIP1
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背景
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Synonyms: Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1)|CD2-binding protein 1|H-PIP|PSTPIP1|CD2BP1
Background: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
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分子量
- 48 kDa
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基因ID
- 9051
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UniProt
- O43586
抗原
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