PRR5 抗体
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北京 101111
Quick Overview for PRR5 抗体 (ABIN7117819)
抗原
See all PRR5 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PRR5 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- proline rich 5(renal)
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亚型
- IgG
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anti-Proline Rich 5 (Renal) (PRR5) (AA 109-388) antibody
PRR5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Proline Rich 5 (Renal) (PRR5) (C-Term) antibodyPRR5 适用: 人, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Proline Rich 5 (Renal) (PRR5) (AA 35-84) antibodyPRR5 适用: 人, 马, Cow, 犬, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Proline Rich 5 (Renal) (PRR5) (N-Term) antibodyPRR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Proline Rich 5 (Renal) (PRR5) (N-Term) antibodyPRR5 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PRR5 (Proline Rich 5 (Renal) (PRR5))
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别名
- PRR5
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背景
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Synonyms: Proline-rich protein 5|Protein observed with Rictor-1 (Protor-1)|PRR5|PROTOR1
Background: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
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分子量
- 33 kDa, 50 kDa
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基因ID
- 55615
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UniProt
- P85299
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途径
- PI3K-Akt Signaling
抗原
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