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PBX1 抗体

This anti-PBX1 antibody is a 兔 多克隆 antibody detecting PBX1 in WB, ELISA, IF 和 IP. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7117746
发货至: 中国

Quick Overview for PBX1 抗体 (ABIN7117746)

抗原

See all PBX1 抗体
PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

适用

  • 25
  • 6
  • 6
  • 2
  • 2
  • 2
  • 1
人, 小鼠, 大鼠

宿主

  • 16
  • 8
  • 1

克隆类型

  • 18
  • 7
多克隆

标记

  • 21
  • 2
  • 1
  • 1
This PBX1 antibody is un-conjugated

应用范围

  • 19
  • 14
  • 8
  • 7
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    pre-B-cell leukemia homeobox 1

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

    别名

    PBX1

    背景

    Synonyms:PRL Background:Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the(1,19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex(PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression(By similarity).

    分子量

    52 kDa

    基因ID

    5087

    UniProt

    P40424
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