PIWIL2 抗体
Quick Overview for PIWIL2 抗体 (ABIN7117541)
抗原
See all PIWIL2 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- piwi-like 2(Drosophila)
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亚型
- IgG
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anti-Piwi-Like 2 (PIWIL2) (C-Term) antibody
PIWIL2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Piwi-Like 2 (PIWIL2) (AA 30-80) antibodyPIWIL2 适用: 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Piwi-Like 2 (PIWIL2) antibodyPIWIL2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Piwi-Like 2 (PIWIL2) (AA 1-973) antibodyPIWIL2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Piwi-Like 2 (PIWIL2) (AA 287-336) antibodyPIWIL2 适用: 人, Cow, 犬, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Piwi-Like 2 (PIWIL2) (AA 90-119), (N-Term) antibodyPIWIL2 适用: 人 WB 宿主: 兔 Polyclonal RB39798 unconjugated
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应用备注
- IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- PIWIL2 (Piwi-Like 2 (PIWIL2))
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别名
- PIWIL2
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背景
- Synonyms:HILI Background:Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8(By similarity). Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors(PubMed:16377660).
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基因ID
- 55124
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UniProt
- Q8TC59
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途径
- Stem Cell Maintenance
抗原
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