PHF2 抗体
Quick Overview for PHF2 抗体 (ABIN7117376)
抗原
See all PHF2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PHF2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- PHD finger protein 2
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亚型
- IgG
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anti-PHD Finger Protein 2 (PHF2) (AA 936-985) antibody
PHF2 适用: 人, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-PHD Finger Protein 2 (PHF2) (AA 2-100) antibodyPHF2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-PHD Finger Protein 2 (PHF2) (Middle Region) antibodyPHF2 适用: 人, 兔, Cow, 马, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PHF2 (PHD Finger Protein 2 (PHF2))
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别名
- PHF2
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背景
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Synonyms: Lysine-specific demethylase PHF2|GRC5|PHD finger protein 2|PHF2|CENP-35|KIAA0662
Background: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA.
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分子量
- 100 kDa, 150 kDa
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基因ID
- 5253
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UniProt
- O75151
抗原
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