PIN1 抗体
Quick Overview for PIN1 抗体 (ABIN7117298)
抗原
See all PIN1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PIN1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- peptidylprolyl cis/trans isomerase, NIMA-interacting 1
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亚型
- IgG
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anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 30-56) antibody
PIN1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) antibodyPIN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 30-56) antibodyPIN1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB22881 unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (N-Term) antibodyPIN1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (pSer16) antibodyPIN1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) antibodyPIN1 适用: 人, 小鼠, 大鼠, Green Monkey IHC (p), IF (cc) 宿主: 小鼠 Monoclonal 5F5 unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 2-163) antibodyPIN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) antibodyPIN1 适用: 人 IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 64-163) antibodyPIN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5A8 unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 64-163) antibodyPIN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F2 unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
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别名
- PIN1
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背景
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Synonyms: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1)|Rotamase Pin1|PIN1
Background: Peptidyl-prolyl cis/trans isomerase(PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro(pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins(PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK(PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation(PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner(PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN(PubMed:22608923).
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分子量
- 18 kDa
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基因ID
- 5300
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UniProt
- Q13526
抗原
-
