PTRH2 抗体
Quick Overview for PTRH2 抗体 (ABIN7117297)
抗原
See all PTRH2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PTRH2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- peptidyl-tRNA hydrolase 2
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亚型
- IgG
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anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibody
PTRH2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibodyPTRH2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 26-55), (N-Term) antibodyPTRH2 适用: 人 WB 宿主: 兔 Polyclonal RB42733 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 100-149) antibodyPTRH2 适用: 人, Cow, 犬, 豚鼠, 马, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (C-Term) antibodyPTRH2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 80-110) antibodyPTRH2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB06095 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (N-Term) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (Middle Region) antibodyPTRH2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
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别名
- PTRH2
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背景
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Synonyms: Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2)|Bcl-2 inhibitor of transcription 1|PTRH2|BIT1|PTH2
Background: The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.
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分子量
- 20 kDa
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基因ID
- 51651
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UniProt
- Q9Y3E5
抗原
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