PARD3 抗体 (AA 180-442)
Quick Overview for PARD3 抗体 (AA 180-442) (ABIN7117224)
抗原
See all PARD3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 180-442
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原理
- PARD3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 180-442aa
Immunogen: Partitioning defective 3 homolog
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亚型
- IgG
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应用备注
- WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:50-1:200, IF: 1:50-1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PARD3 (Par-3 Partitioning Defective 3 Homolog (PARD3))
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别名
- PARD3
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背景
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Synonyms: Partitioning defective 3 homolog (PAR-3, PARD-3)|Atypical PKC isotype-specific-interacting protein (ASIP)|CTCL tumor antigen se2-5|PAR3-alpha|PARD3|PAR3|PAR3A
Background: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination(By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.PARD3 has three splice isoforms at 100 kDa, 150 kDa, and 180 kDa. This polyclonal antibody raised against C-terminal 281 amino acids of human PARD3 recognizes these three isoforms.
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分子量
- 100 kDa, 150 kDa, and 180 kDa
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基因ID
- 56288
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UniProt
- Q8TEW0
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途径
- Cell-Cell Junction Organization
抗原
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