NCOA3 抗体
Quick Overview for NCOA3 抗体 (ABIN7116985)
抗原
See all NCOA3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- NCOA3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- nuclear receptor coactivator 3
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))
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别名
- NCOA3
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背景
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Synonyms: Nuclear receptor coactivator 3 (NCoA-3)|ACTR|Amplified in breast cancer 1 protein (AIB-1)|CBP-interacting protein (pCIP)|Class E basic helix-loop-helix protein 42 (bHLHe42)|Receptor-associated coactivator 3 (RAC-3)|Steroid receptor coactivator protein 3 (SRC-3)|Thyroid hormone receptor activator molecule 1 (TRAM-1)|NCOA3|AIB1|BHLHE42|RAC3|TRAM1
Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids(GR and ER), retinoids(RARs and RXRs), thyroid hormone(TRs), vitamin D3(VDR) and prostanoids(PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
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分子量
- 160 kDa
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基因ID
- 8202
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UniProt
- Q9Y6Q9
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha
抗原
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