NAT10 抗体
Quick Overview for NAT10 抗体 (ABIN7116678)
抗原
See all NAT10 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- NAT10 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- N-acetyltransferase 10(GCN5-related)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))
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别名
- NAT10
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背景
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Synonyms: RNA cytidine acetyltransferase|18S rRNA cytosine acetyltransferase|N-acetyltransferase 10|N-acetyltransferase-like protein (hALP)|NAT10|ALP|KIAA1709
Background: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs(PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine(ac4C) at positions 1337 and 1842 in 18S rRNA(By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis(PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs(By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation(PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division(PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).
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分子量
- 116 kDa
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基因ID
- 55226
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UniProt
- Q9H0A0
抗原
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