MCC 抗体
Quick Overview for MCC 抗体 (ABIN7116539)
抗原
See all MCC 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- mutated in colorectal cancers
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亚型
- IgG
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anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibody
MCC 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 479-611) antibodyMCC 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (Center) antibodyMCC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibodyMCC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- MCC (Mutated in Colorectal Cancers (MCC))
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别名
- MCC
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背景
- Synonyms: Background:Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation(PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway(canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin(CTNB1) transcriptional activity(PubMed:24824780).
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分子量
- 98 kDa , 113-118 kDa
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基因ID
- 4163
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UniProt
- P23508
抗原
-
